The teeth of Giganotosaurus were shorter, less variable and narrower than those of Tyrannosaurus, and were more adapted for slicing flesh as to a blade or knife.
A well-developed olfactory region means that it probably had a good sense of smell. Its skull, although large, had a slender build. It´s arms were long and powerful, tipped with large claws on each toe, that were used to open huge gashes onto the flesh of it´s prey.
Titanosaur fossils have been recovered near the remains of Giganotosaurus, leading to speculation that these carnivores may have preyed on the giant herbivores. Fossils of related carcharodontosaurids grouped closely together may indicate pack hunting, a behavior that could possibly extend to Giganotosaurus itself. Blanco and Mazzetta (2001) estimated that Giganotosaurus might have been capable of running at speeds up to 14 metres per second (31 mph).